Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease.

ABSTRACT:

Background

White matter hyperintensity (WMH) is one of the typical neuroimaging manifestations of cerebral small vessel disease (CSVD), and the WMH correlates closely to cognitive impairment (CI). CSVD patients with WMH own altered topological properties of brain functional network, which is a possible mechanism that leads to CI. This study aims to identify differences in the characteristics of some brain functional network among patients with different grades of WMH and estimates the correlations between these different brain functional network characteristics and cognitive assessment scores.

Methods

110 CSVD patients underwent 3.0 T Magnetic resonance imaging scans and neuropsychological cognitive assessments. WMH of each participant was graded on the basis of Fazekas grad

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8908649 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature