Genetics and Brain Transcriptomics of Completed Suicide.

ABSTRACT:

Objective

The authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing heterogeneity.

Methods

The authors analyzed gene expression (RNA sequencing) from postmortem dorsolateral prefrontal cortex of patients who died by suicide with violent compared with nonviolent means, nonsuicide patients with the same psychiatric disorders, and a neurotypical group (total N=329). They then examined genomic risk scores (GRSs) for each psychiatric disorder included, and GRSs for cognition (IQ) and for suicide attempt, testing how they predict diagnosis or traits (total N=888).

Results

Patients who died by suicide

SUBMITTER: Punzi G 

PROVIDER: S-EPMC8908792 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature