Physiological health indexes predict deterioration and mortality in patients with COVID-19: a comparative study.

ABSTRACT: Old age is a crucial risk factor for severe coronavirus disease 2019 (COVID-19), with serious or fatal outcomes disproportionately affecting older adults compared with the rest of the population. We proposed that the physiological health status and biological age, beyond the chronological age itself, could be the driving trends affecting COVID-19 severity and mortality. A total of 155 participants hospitalized with confirmed COVID-19 aged 26-94 years were recruited for the study. Four different physiological summary indices were calculated: Klemera and Doubal's biological age, PhenoAge, physiological dysregulation (PD; globally and in specific systems), and integrated albunemia. All of these indices significantly predicted the risk of death (p < 0.01) after adjusting for chronological age

SUBMITTER: Strazhesko I 

PROVIDER: S-EPMC8908924 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature