Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity.

ABSTRACT: Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control immunity are still being described. In the context of inflammation and autoimmunity, polyamine levels inversely correlate to autoimmune phenotypes, with lower polyamine levels associated with higher inflammatory responses. Conversely, in the context of cancer, polyamines and polyamine biosynthetic genes positively correlate with the severity of malignancy. Blockade of polyamine metabolism in cancer results in reduced tumor growth, and the effects appear to be mediated by an increase in T-cell infiltration and a pro-inflammatory phenotype o

SUBMITTER: Chia TY 

PROVIDER: S-EPMC8909056 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature