More than a Bubble: Extracellular Vesicle microRNAs in Head and Neck Squamous Cell Carcinoma.

ABSTRACT: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a pivotal regulatory role in a broad variety of biological processes. Dysregulation of miRNAs is associated with several human diseases, particularly cancer. Extracellular vesicles (EVs) are crucial components in intercellular communication. As part of the cargo of EVs, miRNAs are involved in EV-mediated cell-to-cell interactions, including promotion or suppression of tumor development. The knowledge on the molecular mechanisms and clinical importance of EV-miRNAs in head and neck squamous cell carcinoma (HNSCC) has rapidly grown over the past years. In the present review, the current understanding regarding the effect of EV-miRNAs on HNSCC tumorigenesis is summarized, which includes effects on tumor proliferation,

SUBMITTER: Panvongsa W 

PROVIDER: S-EPMC8909139 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature