The Characteristics and Distribution of α2D-, α2B- and α2C-Adrenoceptor Subtypes in Goats.

ABSTRACT: α2-Adrenegic receptors (α2Rs) are important presynaptic modulators of central noradrenergic function (auto receptors) and postsynaptic mediators of many of the widespread effects of catecholamines and related drugs. Studies have shown that ruminants (such as goats and cattle) express special α2DR subtypes in addition to α2BR and α2CR. Real-time quantitative PCR and Western blotting were used to investigate the distribution and density of α2R in different nuclei of the goat central nervous system, selected regions of the spinal cord (L4-L6), and in various peripheral tissues. α2-AR subtype-specific antibodies were injected intrathecally and intracerebroventricularly into the tested goats to block the corresponding subtype of receptors. Pain threshold and physiological parameters were evalua

SUBMITTER: Xu M 

PROVIDER: S-EPMC8909296 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature