Role of Neural (N)-Cadherin in Breast Cancer Cell Stemness and Dormancy in the Bone Microenvironment.

ABSTRACT: Breast cancer cells that interact with spindle-shaped N-Cadherin⁺ Osteoblasts (SNOs) are recognised to become dormant through a Notch2-dependent mechanism. We found that Notch2^High human BrCa MDA-MB231 (MDA) cells also expressed high level of N-Cadherin. This prompted us to hypothesize that N-Cadherin could have a role in MDA-SNO interaction. Of note, the expression of N-Cadherin in MDA cells reduced tumour incidence and bone osteolysis in BrCa mouse model. Moreover, similarly to Notch2^High MDA cells, the N-Cadherin^High MDA cells revealed a high expression of the canonical Haematopoietic Stem cell (HSC) markers, suggesting an HSC mimicry, associated with higher ability to form mammospheres. Interestingly, N-Cadherin^High MDA cells showe

SUBMITTER: Maurizi A 

PROVIDER: S-EPMC8909418 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature