Mechanomimetic 3D Scaffolds as a Humanized In Vitro Model for Ovarian Cancer.

ABSTRACT: The mechanical homeostasis of tissues can be altered in response to trauma or disease, such as cancer, resulting in altered mechanotransduction pathways that have been shown to impact tumor development, progression, and the efficacy of therapeutic approaches. Specifically, ovarian cancer progression is parallel to an increase in tissue stiffness and fibrosis. With in vivo models proving difficult to study, tying tissue mechanics to altered cellular and molecular properties necessitate advanced, tunable, in vitro 3D models able to mimic normal and tumor mechanic features. First, we characterized normal human ovary and high-grade serous (HGSC) ovarian cancer tissue stiffness to precisely mimic their mechanical features on collagen I-based sponge scaffolds, soft (NS) and stiff (MS), respectiv

SUBMITTER: Paradiso F 

PROVIDER: S-EPMC8909508 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature