Anionic Lipids Confine Cytochrome c₂ to the Surface of Bioenergetic Membranes without Compromising Its Interaction with Redox Partners.

ABSTRACT: Cytochrome c₂ (cyt. c₂) is a major element in electron transfer between redox proteins in bioenergetic membranes. While the interaction between cyt. c₂ and anionic lipids abundant in bioenergetic membranes has been reported, their effect on the shuttling activity of cyt. c₂ remains elusive. Here, the effect of anionic lipids on the interaction and binding of cyt. c₂ to the cytochrome bc₁ complex (bc₁) is investigated using a combination of molecular dynamics (MD) and Brownian dynamics (BD) simulations. MD is used to generate thermally accessible conformations of cyt. c₂ and membrane-embedded bc₁, which were subsequently used in mu

SUBMITTER: Chan CK 

PROVIDER: S-EPMC8909606 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature