Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma.

ABSTRACT: Deregulation of mRNA translation is a widespread characteristic of glioblastoma (GBM), aggressive malignant brain tumors that are resistant to conventional therapies. RNA-binding proteins (RBPs) play a critical role in translational regulation, yet the mechanisms and impact of these regulations on cancer development, progression and response to therapy remain to be fully understood. Here, we showed that hnRNP H/F RBPs are potent regulators of translation through several mechanisms that converge to modulate the expression and/or the activity of translation initiation factors. Among these, hnRNP H/F regulate the phosphorylation of eIF4E and its translational targets by controlling RNA splicing of the A-Raf kinase mRNA, which in turn modulates the MEK-ERK/MAPK signaling pathway. The underlyin

SUBMITTER: Le Bras M 

PROVIDER: S-EPMC8909726 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature