Very Late Recurrence in Germ Cell Tumor of the Testis: Lessons and Implications.

ABSTRACT: Very late recurrence (LR), i.e., >5 years after initial presentation, occurs in about 1% of patients with germ cell tumors of the testis (TGCT) and is associated with poor prognosis. We retrospectively reviewed the records of patients at the M. D. Anderson Cancer Center who developed LR > 5 years after their initial diagnosis of TGCT. We identified 25 patients who developed LR between July 2007 and August 2020. The median age at the time of LR was 46 years (range, 29-61). Pathology of LR: somatic transformation to carcinoma or sarcoma-11, nonseminoma with yolk sac tumor or teratoma-11, nonseminoma without yolk sac tumor or teratoma-2, not available-1. With a median follow-up of 3.5 years, 68% of patients are alive 3 years after LR. Patients with prior post-chemotherapy consolidation

SUBMITTER: Moore JA 

PROVIDER: S-EPMC8909729 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature