Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease.

ABSTRACT: Coronary artery disease is a complex cardiovascular disease involving an interplay of genetic and environmental influences over a lifetime. Although considerable progress has been made in understanding lifestyle risk factors, genetic factors identified from genome-wide association studies may capture additional hidden risk undetected by traditional clinical tests. These genetic discoveries have highlighted many candidate genes and pathways dysregulated in the vessel wall, including those involving smooth muscle cell phenotypic modulation and injury responses. Here, we summarize experimental evidence for a few genome-wide significant loci supporting their roles in smooth muscle cell biology and disease. We also discuss molecular quantitative trait locus mapping as a powerful discovery and f

SUBMITTER: Wong D 

PROVIDER: S-EPMC8909916 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature