Mast Cells in the Mammalian Testis and Epididymis-Animal Models and Detection Methods.

ABSTRACT: Mast cells (MCs) are an evolutionary well-conserved type of cells, mediating and modulating allergic responses in innate immunity and tissue remodeling after chronic inflammation. Among other tissues, they inhabit both the testis and epididymis. In the testis, MCs usually appear in the interstitial compartment in humans, but not in other standard experimental models, like rats and mice. MCs seem to be responsible for testicular tissue fibrosis in different causes of infertility. Although experimental animal models follow the effect on MC activation or penetration to the interstitial tissue like in humans to some extent, there is an inconsistency in the available literature regarding experimental design, animal strain, and detection methods used. This comprehensive review offers an insight

SUBMITTER: Himelreich-Peric M 

PROVIDER: S-EPMC8909951 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature