Cytokine and Chemokine Receptor Patterns of Human Malignant Melanoma Cell Lines.

ABSTRACT: Cytokine and chemokine receptors can promote tumor progression, invasion, and metastasis development by inducing different intracellular signaling pathways. The aim of this study was to determine the cytokine and chemokine receptor gene expression patterns in human melanoma cell lines. We found a large set of cytokine and chemokine receptor genes that were significantly differentially expressed between melanoma cell lines that originated from different subtypes of primary melanomas as well as cell lines that originated from melanoma metastases. The relative expressions of two receptor genes (CCR2 and TNFRSF11B) were positively correlated with the invasive potential of the cell lines, whereas a negative correlation was observed for the TNFRSF14 gene expression. We also found a small set of

SUBMITTER: Koroknai V 

PROVIDER: S-EPMC8910570 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature