Surface Functionalization of Ureteral Stents-Based Polyurethane: Engineering Antibacterial Coatings.

ABSTRACT: Bacterial colonization of polyurethane (PU) ureteral stents usually leads to severe and challenging clinical complications. As such, there is an increasing demand for an effective response to this unmet medical challenge. In this study, we offer a strategy based on the functionalization of PU stents with chitosan-fatty acid (CS-FA) derivatives to prevent bacterial colonization. Three different fatty acids (FAs), namely stearic acid (SA), oleic acid (OA), and linoleic acid (LinA), were successfully grafted onto chitosan (CS) polymeric chains. Afterwards, CS-FA derivatives-based solutions were coated on the surface of PU stents. The biological performance of the modified PU stents was evaluated against the L929 cell line, confirming negligible cytotoxicity of the developed coating formulatio

SUBMITTER: Ecevit K 

PROVIDER: S-EPMC8910958 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature