Expression of the AHPND Toxins PirA^vp and PirB^vp Is Regulated by Components of the Vibrio parahaemolyticus Quorum Sensing (QS) System.

ABSTRACT: Acute hepatopancreatic necrosis disease (AHPND) in shrimp is caused by Vibrio strains that harbor a pVA1-like plasmid containing the pirA and pirB genes. It is also known that the production of the PirA and PirB proteins, which are the key factors that drive the observed symptoms of AHPND, can be influenced by environmental conditions and that this leads to changes in the virulence of the bacteria. However, to our knowledge, the mechanisms involved in regulating the expression of the pirA/pirB genes have not previously been investigated. In this study, we show that in the AHPND-causing Vibrio parahaemolyticus 3HP strain, the pirA^vp and pirB^vp genes are highly expressed in the early log phase of the growth curve.

SUBMITTER: Lin SJ 

PROVIDER: S-EPMC8911003 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature