Design, Synthesis, and Biological Evaluation of New Azulene-Containing Chalcones.

ABSTRACT: Azulene-containing chalcones have been synthesized via Claisen-Schmidt condensation reaction. Their chemical structure has been established by spectroscopic methods where the ¹H-NMR spectra suggested that the title chalcones were geometrically pure and configured trans (J = 15 Hz). The influence of functional groups from azulene-containing chalcones on the biological activity of the 2-propen-1-one unit was investigated for the first time. This study presents optical and fluorescent investigations, QSAR studies, and biological activity of 10 novel compounds. These chalcones were evaluated for their antimicrobial activity against Gram-positive and Gram-negative bacteria. The results revealed that most of the synthesized compounds showed inhibition against Gram-negative micr

SUBMITTER: Bala D 

PROVIDER: S-EPMC8911025 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature