Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics.

ABSTRACT: The growing number of drug-resistant pathogenic bacteria poses a global threat to human health. For this reason, the search for ways to enhance the antibacterial activity of existing antibiotics is now an urgent medical task. The aim of this study was to develop novel delivery systems for polymyxins to improve their antimicrobial properties against various infections. For this, hybrid core-shell nanoparticles, consisting of silver core and a poly(glutamic acid) shell capable of polymyxin binding, were developed and carefully investigated. Characterization of the hybrid nanoparticles revealed a hydrodynamic diameter of approximately 100 nm and a negative electrokinetic potential. The nanoparticles demonstrated a lack of cytotoxicity, a low uptake by macrophages, and their own antimicrobial

SUBMITTER: Iudin D 

PROVIDER: S-EPMC8911036 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature