Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.

ABSTRACT: The endogenous protease furin is a key protein in many different diseases, such as cancer and infections. For this reason, a wide range of studies has focused on targeting furin from a therapeutic point of view. Our main objective consisted of identifying new compounds that could enlarge the furin inhibitor arsenal; secondarily, we assayed their adjuvant effect in combination with a known furin inhibitor, CMK, which avoids the SARS-CoV-2 S protein cleavage by means of that inhibition. Virtual screening was carried out to identify potential furin inhibitors. The inhibition of physiological and purified recombinant furin by screening selected compounds, Clexane, and these drugs in combination with CMK was assayed in fluorogenic tests by using a specific furin substrate. The effects of the se

SUBMITTER: Zaragoza-Huesca D 

PROVIDER: S-EPMC8911046 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature