Free Cholesterol Accelerates Aβ Self-Assembly on Membranes at Physiological Concentration.

ABSTRACT: The effects of membranes on the early-stage aggregation of amyloid β (Aβ) have come to light as potential mechanisms by which neurotoxic species are formed in Alzheimer's disease. We have shown that direct Aβ-membrane interactions dramatically enhance the Aβ aggregation, allowing for oligomer assembly at physiologically low concentrations of the monomer. Membrane composition is also a crucial factor in this process. Our results showed that apart from phospholipids composition, cholesterol in membranes significantly enhances the aggregation kinetics. It has been reported that free cholesterol is present in plaques. Here we report that free cholesterol, along with its presence inside the membrane, further accelerate the aggregation process by producing aggregates more rapidly and of signific

SUBMITTER: Hashemi M 

PROVIDER: S-EPMC8911190 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature