Future Treatment Options in Systemic Sclerosis-Potential Targets and Ongoing Clinical Trials.

ABSTRACT: Systemic sclerosis is an autoimmune connective tissue disease characterized by vasculopathy and fibrosis of the skin and internal organs. The pathogenesis of systemic sclerosis is very complex. Mediators produced by immune cells are involved in the inflammatory processes occurring in the tissues. The currently available therapeutic options are often insufficient to halt disease progress. This article presents an overview of potential therapeutic targets and the pipeline of possible future therapeutic options. It is based on research of clinical trials involving novel, unestablished methods of treatment. Increasing knowledge of the processes and mediators involved in systemic scleroderma has led to the initiation of drug trials with therapeutic targets of CD28-CD80/86, CD19, CCL24, CD20, CD

SUBMITTER: Bohdziewicz A 

PROVIDER: S-EPMC8911443 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature