Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review.

ABSTRACT: Human papillomavirus (HPV) still represents an important threat to health worldwide. Better therapy in terms of further improvement of outcomes and attenuation of related side-effects is desirable. The pharmaceutical industry has always targeted natural substances-phytochemicals in particular-to identify lead compounds to be clinically validated and industrially produced as antiviral and anticancer drugs. In the field of HPV, numerous naturally occurring bioactives and dietary phytochemicals have been investigated as potentially valuable in vitro and in vivo. Interference with several pathways and improvement of the efficacy of chemotherapeutic agents have been demonstrated. Notably, some clinical trials have been conducted. Despite being endowed with general safety, these natural substanc

SUBMITTER: Massa S 

PROVIDER: S-EPMC8911515 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature