Optimization of Biocompatibility for a Hydrophilic Biological Molecule Encapsulation System.

ABSTRACT: Despite considerable advances in recent years, challenges in delivery and storage of biological drugs persist and may delay or prohibit their clinical application. Though nanoparticle-based approaches for small molecule drug encapsulation are mature, encapsulation of proteins remains problematic due to destabilization of the protein. Reverse micelles composed of decylmonoacyl glycerol (10MAG) and lauryldimethylamino-N-oxide (LDAO) in low-viscosity alkanes have been shown to preserve the structure and stability of a wide range of biological macromolecules. Here, we present a first step on developing this system as a future platform for storage and delivery of biological drugs by replacing the non-biocompatible alkane solvent with solvents currently used in small molecule delivery systems. U

SUBMITTER: Sanders AB 

PROVIDER: S-EPMC8911823 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature