Design of Oligourea-Based Foldamers with Antibacterial and Antifungal Activities.

ABSTRACT: There is an urgent need to develop new therapeutic strategies to fight the emergence of multidrug resistant bacteria. Many antimicrobial peptides (AMPs) have been identified and characterized, but clinical translation has been limited partly due to their structural instability and degradability in physiological environments. The use of unnatural backbones leading to foldamers can generate peptidomimetics with improved properties and conformational stability. We recently reported the successful design of urea-based eukaryotic cell-penetrating foldamers (CPFs). Since cell-penetrating peptides and AMPs generally share many common features, we prepared new sequences derived from CPFs by varying the distribution of histidine- and arginine-type residues at the surface of the oligourea helix, and

SUBMITTER: Tallet L 

PROVIDER: S-EPMC8911826 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature