The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity.

ABSTRACT: A large number of aerospace practices have confirmed that the aerospace microgravity environment can lead to cognitive function decline. Mitochondria are the most important energy metabolism organelles, and some studies demonstrate that the areospace microgravity environment can cause mitochondrial dysfunction. However, the relationships between cognitive function decline and mitochondrial dysfunction in the microgravity environment have not been elucidated. In this study, we simulated the microgravity environment in the Sprague-Dawley (SD) rats by -30° tail suspension for 28 days. We then investigated the changes of mitochondrial morphology and proteomics in the hippocampus. The electron microscopy results showed that the 28-day tail suspension increased the mitochondria number and size o

SUBMITTER: Ji G 

PROVIDER: S-EPMC8912132 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature