Efficacy of propylthiouracil in the treatment of pregnancy with hyperthyroidism and its effect on pregnancy outcomes: A meta-analysis.

ABSTRACT:

Background

Hyperthyroidism affects about 0.2%-2.7% of all pregnancies, and is generally treated with propylthiouracil (PTU). However, previous studies about the effects of propylthiouracil on maternal or foetal are contentious.

Objective

This meta-analysis was carried out to investigate the safety and efficacy of propylthiouracil during pregnancy.

Materials and methods

PubMed, EBSCO, Embase, Scopus, Web of Science, Cochrane, CNKI, Wanfang and VIP database were searched from inception until August 31, 2021 for all available randomized controlled trials (RCTs) or cohort studies that evaluated the efficacy of propylthiouracil and its effects on pregnancy outcomes. Odds ratio (OR) and 95% confidence interval (CI) were used for binary variables, weighted mean difference (W

SUBMITTER: Miao Y 

PROVIDER: S-EPMC8912150 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature