The antipyretic effectiveness of dipyrone in the intensive care unit: A retrospective cohort study.

ABSTRACT:

Introduction

Dipyrone (metamizol) is regularly used in critical care for pain and fever treatment, especially in Germany and Spain. However, indication for antipyretic therapy in critically ill patients is currently unclear and data for both the risk and benefit of dipyrone treatment in the intensive care environment are scarce. We hypothesized that antipyretic efficiency of dipyrone would not exceed antipyretic efficiency of acetaminophen. We therefore aimed to compare temperature courses in critically ill patients receiving either intravenous dipyrone, acetaminophen or no antipyretic medication.

Material and methods

We included 937 intensive care unit (ICU) patients with body temperature recordings of at least 37.5°C. We investigated temperature decrease associated with di

SUBMITTER: Gillmann HJ 

PROVIDER: S-EPMC8912151 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature