Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus.

ABSTRACT:

Background

Sarcopenia is characterized by the age-associated loss of skeletal muscle mass and strength that develops progressively and plays an important role in the disability of the elderly. It has received growing attention over the last decade and has been implicated as both a cause and consequence of type 2 diabetes mellitus (T2DM). The existence of T2DM could increase the risk of developing sarcopenia through multiple mechanisms including advanced glycation end-product accumulation. Meanwhile, sarcopenia would alter glucose disposal and may contribute to the development and progression of T2DM due to reduced muscle mass.

Methods

We implemented transcriptomic analysis of skeletal muscle biopsy specimens in sarcopenia patients and proliferating myoblasts or differentiate

SUBMITTER: Huang S 

PROVIDER: S-EPMC8912249 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature