Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil.

ABSTRACT: Given the relationship between vitamin D deficiency (VDD) and adverse outcomes of metabolic diseases, we investigated the interplay of dietary and genetic components on vitamin D levels and metabolic traits in young adults from Brazil. Genetic analysis, dietary intake, and anthropometric and biochemical measurements were performed in 187 healthy young adults (19−24 years). Genetic risk scores (GRS) from six genetic variants associated with vitamin D (vitamin D-GRS) and 10 genetic variants associated with metabolic disease (metabolic-GRS) were constructed. High vitamin D-GRS showed a significant association with low 25(OH)D concentrations (p = 0.001) and high metabolic-GRS showed a significant association with high fasting insulin concentrations (p = 0.045). A significant interaction was fo

SUBMITTER: Alathari BE 

PROVIDER: S-EPMC8912678 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature