Extracellular Fluid Flow Induces Shallow Quiescence Through Physical and Biochemical Cues.

ABSTRACT: The balance between cell quiescence and proliferation is fundamental to tissue physiology and homeostasis. Recent studies have shown that quiescence is not a passive and homogeneous state but actively maintained and heterogeneous. These cellular characteristics associated with quiescence were observed primarily in cultured cells under a static medium. However, cells in vivo face different microenvironmental conditions, particularly, under interstitial fluid flows distributed through extracellular matrices. Interstitial fluid flow exerts shear stress on cells and matrix strain, and results in continuous replacement of extracellular factors. In this study, we analyzed individual cells under varying fluid flow rates in microfluidic devices. We found quiescence characteristics previousl

SUBMITTER: Liu B 

PROVIDER: S-EPMC8912726 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature