Whole genome sequencing of Neisseria meningitidis Y isolates collected in the Czech Republic in 1993-2018.

ABSTRACT:

Introduction

The study presents the analysis of whole genome sequencing (WGS) data for Neisseria meningitidis serogroup Y isolates collected in the Czech Republic and their comparison to other countries. The aim of the study was to determine whether there are lineages of N. meningitidis serogroup Y in the Czech Republic genetically related to foreign ones that have been causing an increase of the morbidity and the mortality of invasive meningococcal disease (IMD) world-wide recently.

Material and methods

The WGS data of 43 Czech N. meningitidis Y isolates, 35 from IMD and 8 from healthy carriers were analysed. Due to the potential of meningococcal B vaccines to induce protection against non-B serogroups, the coverage of Czech isolates of N. meningitidis Y by these vaccines w

SUBMITTER: Honskus M 

PROVIDER: S-EPMC8912901 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature