Analysis of Potential Hub Genes for Neuropathic Pain Based on Differential Expression in Rat Models.

ABSTRACT:

Objective

Neuropathic pain (NP) is a type of intractable chronic pain with complicated etiology. The exact molecular mechanism underlying NP remains unclear. In this study, we searched for molecular biomarkers of NP.

Methods

Differentially expressed genes (DEGs) were predicted by analyzing three NP-related microarray datasets in Gene Expression Omnibus with robust rank aggregation. A weighted gene coexpression network analysis was conducted to construct a network of differentially expressed genes, followed by the evaluation of correlations between gene sets and the determination of hub genes. The candidate genes from the key module were identified using a gene set enrichment analysis.

Results

In total, 353 upregulated and 383 downregulated genes were obtained, among w

SUBMITTER: Bai J 

PROVIDER: S-EPMC8913144 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature