Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke.

ABSTRACT:

Background

Atrial fibrillation (AF) is one of the most prevalent causes of cryptogenic stroke. Also, apart from AF itself, structural and remodelling changes in the atria might be an underlying cause of cryptogenic stroke. We aimed to discover circulating proteins and reveal pathways altered in AF and atrial cardiomyopathy, measured by left atrial volume index (LAVI) and peak atrial longitudinal strain (PALS), in patients with cryptogenic stroke.

Methods

An aptamer array (including 1310 proteins) was measured in the blood of 20 cryptogenic stroke patients monitored during 28 days with a Holter device as a case-control study of the Crypto-AF cohort. Protein levels were compared between patients with (n = 10) and without AF (n = 10) after stroke, and the best candidates were t

SUBMITTER: Pala E 

PROVIDER: S-EPMC8913305 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature