Sex-specific involvement of the Notch-JAG pathway in social recognition.

ABSTRACT: Under the hypothesis that olfactory neural epithelium gene expression profiles may be useful to look for disease-relevant neuronal signatures, we examined microarray gene expression in olfactory neuronal cells and underscored Notch-JAG pathway molecules in association with schizophrenia (SZ). The microarray profiling study underscored JAG1 as the most promising candidate. Combined with further validation with real-time PCR, downregulation of NOTCH1 was statistically significant. Accordingly, we reverse-translated the significant finding from a surrogate tissue for neurons, and studied the behavioral profile of Notch1^+/- mice. We found a specific impairment in social novelty recognition, whereas other behaviors, such as sociability, novel object recognition and olfaction of socia

SUBMITTER: Jaaro-Peled H 

PROVIDER: S-EPMC8913639 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature