A multifaceted educational intervention improved anti-infectious measures but had no effect on mortality in patients with severe sepsis.

ABSTRACT: Sepsis is a major reason for preventable hospital deaths. A cluster-randomized controlled trial on an educational intervention did not show improvements of sepsis management or outcome. We now aimed to test an improved implementation strategy in a second intervention phase in which new intervention hospitals (former controls) received a multifaceted educational intervention, while controls (former intervention hospitals) only received feedback of quality indicators. Changes in outcomes from the first to the second intervention phase were compared between groups using hierarchical generalized linear models controlling for possible confounders. During the two phases, 19 control hospitals included 4050 patients with sepsis and 21 intervention hospitals included 2526 patients. 28-day mortality

SUBMITTER: Schwarzkopf D 

PROVIDER: S-EPMC8913650 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature