Causal biological network models for reactive astrogliosis: a systems approach to neuroinflammation.

ABSTRACT: Astrocytes play a central role in the neuroimmune response by responding to CNS pathologies with diverse molecular and morphological changes during the process of reactive astrogliosis. Here, we used a computational biological network model and mathematical algorithms that allow the interpretation of high-throughput transcriptomic datasets in the context of known biology to study reactive astrogliosis. We gathered available mechanistic information from the literature into a comprehensive causal biological network (CBN) model of astrocyte reactivity. The CBN model was built in the Biological Expression Language, which is both human-readable and computable. We characterized the CBN with a network analysis of highly connected nodes and demonstrated that the CBN captures relevant astrocyte bio

SUBMITTER: Barkhuizen M 

PROVIDER: S-EPMC8913664 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature