High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury.

ABSTRACT: Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such systems is extremely challenging, as their loading capacity is inherently limited by the compatibility between drug molecules and carrier materials. To mitigate the drug-carrier compatibility limitation towards therapeutics encapsulation, we developed a sequential solidification strategy. In this strategy, the precisely controlled diffusion of solvents from droplets ensures the fast in-droplet precipitation of drug molecules prior to the solidification of polymer materials. After polymer solidification, a mass of drug nanoparticles is embedded in the polymer matrix, forming a nano-in-micro stru

SUBMITTER: Li W 

PROVIDER: S-EPMC8913677 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature