Modeling material transport regulation and traffic jam in neurons using PDE-constrained optimization.

ABSTRACT: The intracellular transport process plays an important role in delivering essential materials throughout branched geometries of neurons for their survival and function. Many neurodegenerative diseases have been associated with the disruption of transport. Therefore, it is essential to study how neurons control the transport process to localize materials to necessary locations. Here, we develop a novel optimization model to simulate the traffic regulation mechanism of material transport in complex geometries of neurons. The transport is controlled to avoid traffic jam of materials by minimizing a pre-defined objective function. The optimization subjects to a set of partial differential equation (PDE) constraints that describe the material transport process based on a macroscopic molecular-m

SUBMITTER: Li A 

PROVIDER: S-EPMC8913697 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature