A Prognostic Model of Bladder Cancer Based on Metabolism-Related Long Non-Coding RNAs.

ABSTRACT:

Background

Some studies have revealed a close relationship between metabolism-related genes and the prognosis of bladder cancer. However, the relationship between metabolism-related long non-coding RNAs (lncRNA) regulating the expression of genetic material and bladder cancer is still blank. From this, we developed and validated a prognostic model based on metabolism-associated lncRNA to analyze the prognosis of bladder cancer.

Methods

Gene expression, lncRNA sequencing data, and related clinical information were extracted from The Cancer Genome Atlas (TCGA). And we downloaded metabolism-related gene sets from the human metabolism database. Differential expression analysis is used to screen differentially expressed metabolism-related genes and lncRNAs between tumors and para

SUBMITTER: Hu J 

PROVIDER: S-EPMC8913725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature