High-throughput synthesis of CeO₂ nanoparticles for transparent nanocomposites repelling Pseudomonas aeruginosa biofilms.

ABSTRACT: Preventing bacteria from adhering to material surfaces is an important technical problem and a major cause of infection. One of nature's defense strategies against bacterial colonization is based on the biohalogenation of signal substances that interfere with bacterial communication. Biohalogenation is catalyzed by haloperoxidases, a class of metal-dependent enzymes whose activity can be mimicked by ceria nanoparticles. Transparent CeO₂/polycarbonate surfaces that prevent adhesion, proliferation, and spread of Pseudomonas aeruginosa PA14 were manufactured. Large amounts of monodisperse CeO₂ nanoparticles were synthesized in segmented flow using a high-throughput microfluidic benchtop system using water/benzyl alcohol mixtures and oleylamine as capping agent. This redu

SUBMITTER: Sarif M 

PROVIDER: S-EPMC8913809 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature