Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in a variety of clinical symptoms ranging from no or mild to severe disease. Currently, there are multiple postulated mechanisms that may push a moderate to severe disease into a critical state. Human serum contains abundant evidence of the immune status following infection. Cytokines, chemokines, and antibodies can be assayed to determine the extent to which a patient responded to a pathogen. We examined serum and plasma from a cohort of patients infected with SARS-CoV-2 early in the pandemic and compared them to negative-control sera. Cytokine and chemokine concentrations varied depending on the severity of infection, and antibody responses were significantly increased in severe cases compared to mild to moderate infect

SUBMITTER: Griffin AJ 

PROVIDER: S-EPMC8913826 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature