Generalized Uncoupled Bone Remodeling Associated With Delayed Healing of Fatigue Fractures.

ABSTRACT: Fatigue fractures in bones are common injuries with load-bearing activities, during which the remodeling aimed at removing microdamage has been suggested to play a role in increasing related fracture risk. Much attention has been given to the uncoupling between osteoclastic bone resorption and osteoblastic osteogenesis in fatigue fracture cases; however, the underlying pathophysiologic mechanisms of impaired fracture healing are yet unknown. Here we report multiple fatigue fractures in a physically active woman receiving contraceptive pills for years. Her fracture healing was remarkably slow, although she has been otherwise healthy. The patient underwent bone biopsy of the iliac crest that showed remarkable peritrabecular fibrosis with increased osteoclastic bone resorption combined with r

SUBMITTER: Tong X 

PROVIDER: S-EPMC8914151 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature