Immunotherapy in HER2-Positive Breast Cancer: A Systematic Review.
Ontology highlight
ABSTRACT: Introduction
The clinical outcome of HER2-positive breast cancer patients changed with the use of anti-Her therapies, though it still remains an aggressive and fatal disease. Implementation of immune checkpoint inhibitors in HER2-positive Breast cancer is a concept supported by the reported biological and preclinical data.Methods
We conducted a systematic review of the current literature involving immune checkpoint inhibitors alone or in combination with targeted therapies or chemotherapy finalized or running in HER2-positive breast cancer.Results
Twelve clinical trials and 2 case reports were identified in our study.Conclusion
The reported clinical trials highlight that checkpoint inhibition seems to be promising in metastatic, neoadjuvant, and adjuvant settings of HER2-positive breast cancer.
SUBMITTER: Kyriazoglou A
PROVIDER: S-EPMC8914190 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Immunotherapy in HER2-Positive Breast Cancer: A Systematic Review.
Kyriazoglou Anastasios A Kaparelou Maria M Goumas Georgios G Liontos Michael M Zakopoulou Roubini R Zografos Eleni E Zygogianni Anna A Dimopoulos Meletios Athanasios MA Zagouri Flora F
Breast care (Basel, Switzerland) 20210329 1
<h4>Introduction</h4>The clinical outcome of HER2-positive breast cancer patients changed with the use of anti-Her therapies, though it still remains an aggressive and fatal disease. Implementation of immune checkpoint inhibitors in HER2-positive Breast cancer is a concept supported by the reported biological and preclinical data.<h4>Methods</h4>We conducted a systematic review of the current literature involving immune checkpoint inhibitors alone or in combination with targeted therapies or che ...[more]
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