System-Level Analysis of Transcriptional and Translational Regulatory Elements in Streptomyces griseus.

ABSTRACT: Bacteria belonging to Streptomyces have the ability to produce a wide range of secondary metabolites through a shift from primary to secondary metabolism regulated by complex networks activated after vegetative growth terminates. Despite considerable effort to understand the regulatory elements governing gene expression related to primary and secondary metabolism in Streptomyces, system-level information remains limited. In this study, we integrated four multi-omics datasets from Streptomyces griseus NBRC 13350: RNA-seq, ribosome profiling, dRNA-seq, and Term-Seq, to analyze the regulatory elements of transcription and translation of differentially expressed genes during cell growth. With the functional enrichment of gene expression in different growth phases, one sigm

SUBMITTER: Hwang S 

PROVIDER: S-EPMC8914203 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature