Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea.

ABSTRACT: The key auditory signature that may associate peripheral hearing with central auditory cognitive defects remains elusive. Suggesting the involvement of stress receptors, we here deleted the mineralocorticoid and glucocorticoid receptors (MR and GR) using a CaMKIIα-based tamoxifen-inducible Cre^ERT2/loxP approach to generate mice with single or double deletion of central but not cochlear MR and GR. Hearing thresholds of MRGR^{CaMKIIαCreERT2} conditional knockouts (cKO) were unchanged, whereas auditory nerve fiber (ANF) responses were larger and faster and auditory steady state responses were improved. Subsequent analysis of single MR or GR cKO revealed discrete roles for both, central MR and GR on cochlear functions. Limbic MR deletion re

SUBMITTER: Marchetta P 

PROVIDER: S-EPMC8914323 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature