Clinical pharmacology of cytotoxic drugs in neonates and infants: Providing evidence-based dosing guidance.

ABSTRACT: Cancer in neonates and infants is a rare but challenging entity. Treatment is complicated by marked physiological changes during the first year of life, excess rates of toxicity, mortality, and late effects. Dose optimisation of chemotherapeutics may be an important step to improving outcomes. Body size-based dosing is used for most anticancer drugs used in infants. However, dose regimens are generally not evidence based, and dosing strategies are frequently inconsistent between tumour types and treatment protocols. In this review, we collate available pharmacological evidence supporting dosing regimens in infants for a wide range of cytotoxic drugs. A systematic review was conducted, and available data ranked by a level of evidence (1-5) and a grade of recommendation (A-D) provided on a c

SUBMITTER: Nijstad AL 

PROVIDER: S-EPMC8914347 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature