Comparative genomics of <i>Bordetella pertussis</i> isolates from New Zealand, a country with an uncommonly high incidence of whooping cough.

ABSTRACT: Whooping cough, the respiratory disease caused by Bordetella pertussis, has undergone a wide-spread resurgence over the last several decades. Previously, we developed a pipeline to assemble the repetitive B. pertussis genome into closed sequences using hybrid nanopore and Illumina sequencing. Here, this sequencing pipeline was used to conduct a more high-throughput, longitudinal screen of 66 strains isolated between 1982 and 2018 in New Zealand. New Zealand has a higher incidence of whooping cough than many other countries; usually at least twice as many cases per 100000 people as the USA and UK and often even higher, despite similar rates of vaccine uptake. To the best of our knowledge, these strains are the first New Zealand B. pertussis isolates to be sequenced. The

SUBMITTER: Ring N 

PROVIDER: S-EPMC8914352 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature