The promiscuous and highly mobile resistome of Acinetobacter baumannii.

ABSTRACT: Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the whole resistome of Acinetobacter baumannii, a very important nosocomial pathogen. Here we analyse 1450+ genomes (covering >40 countries and >4 decades) to infer the global population dynamics of the resistome of this species. We show that gene flow and horizontal transfer have driven the dissemination of AR genes in A. baumannii. We found considerable variation in AR gene content across lineages. Although the individual AR gene histories have been affected by recombination, the AR gene content has been shaped by the phylogeny. Furthermore, many AR genes have been transferre

SUBMITTER: Hernandez-Gonzalez IL 

PROVIDER: S-EPMC8914355 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature