Evaluation of the Response of HNSCC Cell Lines to γ-Rays and ¹²C Ions: Can Radioresistant Tumors Be Identified and Selected for ¹²C Ion Radiotherapy?

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Thirty percent of patients will experience locoregional recurrence for which median survival is less than 1 year. Factors contributing to treatment failure include inherent resistance to X-rays and chemotherapy, hypoxia, epithelial to mesenchymal transition, and immune suppression. The unique properties of ¹²C radiotherapy including enhanced cell killing, a decreased oxygen enhancement ratio, generation of complex DNA damage, and the potential to overcome immune suppression make its application well suited to the treatment of HNSCC. We examined the ¹²C radioresponse of five HNSCC cell lines, whose surviving fraction at 3.5 Gy ranged from average to resistant when compared with

SUBMITTER: Ding L 

PROVIDER: S-EPMC8914432 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature