Liquid Biopsy-based Precision Therapy in Patients with Advanced Solid Tumors: A Real-world Experience from a Community-based Oncology Practice.

ABSTRACT:

Background

Liquid biopsy testing offers a significant potential in selecting signal-matched therapies for advanced solid malignancies. The feasibility of liquid biopsy testing in a community-based oncology practice, and its actual impact on selecting signal-matched therapies, and subsequent survival effects have not previously been reported.

Patients and methods

A retrospective chart review was conducted on adult patients with advanced solid cancer tested with a liquid-biopsy assay between December 2018 and 2019, in a community oncology practice. The impact of testing on treatment assignment and survival was assessed at 1-year follow-up.

Results

A total of 178 patients underwent testing. A positive test was reported in 140/178 patients (78.7%), of whom 75% had an acti

SUBMITTER: Choucair K 

PROVIDER: S-EPMC8914479 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature